Our Research
Pioneering collaborative research that transforms our understanding of autoimmune neurological conditions and accelerates the path to better treatments.
Featured Research
Neurologic Outcomes in People with Multiple Sclerosis Treated with Immune Checkpoint Inhibitors
Quinn CM, Rajarajan P, Gill AJ, Kopinsky H, Wolf AB, Soares de Camargo C, Lamb J, Bacon TE, Murray JC, Probasco JC, Galetta KM, Kantor D, Coyle P, Bhise V, Alvarez E, Conway SE, Bhattacharyya S, Kister I
This comprehensive study represents the first systematic analysis of neurological safety outcomes in multiple sclerosis (MS) patients receiving immune checkpoint inhibitor (ICI) therapy for concurrent malignancies. Through a retrospective multicenter cohort study involving 31 MS patients treated with ICIs, we investigated the complex interactions between cancer immunotherapy and pre-existing autoimmune neuroinflammation. The study utilized standardized neurological assessments, MRI imaging protocols, and immunological biomarker analysis to evaluate both MS disease activity and treatment-related neurological adverse events. Key findings demonstrate that while ICI therapy can potentially exacerbate MS symptoms in a subset of patients, careful monitoring and interdisciplinary management approaches can mitigate these risks. The research provides evidence-based guidance for oncologists and neurologists managing this challenging patient population, establishing monitoring protocols and risk stratification strategies that balance cancer treatment efficacy with neurological safety.
View on PubMed
Research Focus
Our consortium investigates the full spectrum of autoimmune neurological conditions, from multiple sclerosis and neuromyelitis optica to rare encephalitis syndromes. We combine cutting-edge laboratory research with large-scale clinical studies to uncover new therapeutic targets and treatment strategies.
Active Initiatives
We’re currently leading multi-site clinical trials, biomarker discovery studies, and innovative treatment development programs. Our researchers are investigating novel immunotherapies, developing better diagnostic tools, and creating personalized treatment approaches that could revolutionize patient care.
Scientific Impact
Our collaborative research generates high-impact publications in leading scientific journals, contributing essential knowledge to the global research community. We’re committed to sharing our findings openly to accelerate progress for all researchers working in autoimmune neurology.
.png)
